Sentence examples for binding which can be from inspiring English sources

The generated models provide a site-specific insight into the structural requirements PPAR γ binding which can be used to design and develop potent antidiabetic compounds.

This hybrid methodology has the advantage of the inclusion of quantum effects such as ligand polarization upon binding, which can be very important when highly polarizable groups are embedded in anisotropic environments, for example in metal-containing active sites.

Also, the significantly over-represented molecular functions of human calpain substrates are protein activity and various molecular binding, which can be dynamically regulated by cleavage (Supplementary Table S3).

TFIID-promoter binding, which can be further stabilized by TFIIA, creates a platform for TFIIB loading, which in turn allows the engagement of TFIIF and Pol II.

Thus, here we report, for the first time, that therapeutic doses of methylphenidate administered orally reduce F-fallypride binding, which can be attributed to methylphenidate-induced increases in synaptic dopamine levels.

RAI is based on the understanding that sensitization depends quantitatively on the degree of such binding, which can be estimated by the rate constant for the reaction of the compound with specific nucleophiles.

The rat theta-class glutathione transferase T2-2 (rGST T2-2) presents an ideal scaffold for the design of a novel GPX catalyst because it already binds GSH and contains a serine close to the substrate binding site, which can be chemically modified to bind selenium.

NP1 is a receptor for vascular endothelial growth factor (VEGF) as well as Sema3A, although these ligands occupy distinct binding sites which can be targeted separately by blocking antibodies [ 26, 33] and binding stimulates association with different co-receptors (plexins for Sema3A and VEGFR1/2 for VEGF), and different downstream signalling pathways at least in neuronal cells (reviewed in [ 57]).

Formation of such binding intermediates results in the structural changes in a partner molecule leading to the exposure of its "hidden" binding site, which can be accessed by an IDP due to its structural flexibility.

Fusion reactions between light elements, like fission reactions that split heavy elements, release energy because of a key feature of nuclear matter called the binding energy, which can be released through fusion or fission.

These analogs serve as useful molecular probes to explore the secondary binding site, which can be exploited in designing more potent DAAO inhibitors.