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For the up-regulated genes, cell cycle and ATP binding were the most significant functional categories.
In cellular function, DNA binding and protein binding were the most common terms with 18%, and 17% respectively.
In MG patients without thymoma versus healthy controls, GOCC platelet alpha granule and GOMF chemokine receptor binding were the most enriched among the top 200 GO terms.
When GO categories were assigned to these targets, six molecular function categories predominated; among these, "hydrolase activity", "nucleoside binding", and "nucleotide binding" were the most highly represented.
"Embryonic development ending in birth or egg hatching" and "protein binding" were the most dominant terms in the categories of Biological Process and Molecular Function, respectively.
According to molecular function, the best protein matches, those that were involved in translation, structural functions, calcium and actin binding were the most conserved, which agrees with the initial biological process categorization.
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Metal ion, nucleic acid, and nucleotide binding are the most represented subcategories within the Binding activity category perhaps reflective of the need for biosynthetic and repair activity associated with rehydration of moss cells.
It appears that subsequent complement activation following anti-PEG IgM binding is the most important step in dictating the in vivo fate of PEGylated products.
Covalent binding is the most obvious interpretation of these data.
Another form of degradation, more extensively verified, is the detachment of pigments, mainly of azurite applied especially on line fillers, initial backgrounds and flowers the grain size of the pigments, along with interaction with the protein binding, are the most likely explanations for this phenomenon, but it is also necessary to continue this investigation.
Protein binding was the most abundant GO term within the molecular function category (Fig. 1).
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