Sentence examples for binding were mutated to from inspiring English sources

When the tyrosine phosphorylation sites for PI3K binding were mutated to phenylalanine, PDGFRα lost the capacity to transform mouse astrocytes, both in vitro in soft agar and in vivo in the brain of mice.

Tallquist and colleagues have generated a series of hypomorphic alleles of Pdgfrb in which different numbers of tyrosine residues, which are normally auto-phosphorylated upon ligand binding, are mutated to phenylalanine residues [ 124].

Several residues lining the putative binding acyl chain binding site were mutated to purturb substrate binding.

Unlabeled wildtype annexin A5, with high-affinity binding to PS, and the quadruple-mutant, M1234 annexin A5, where all Ca2+-dependent binding sites were mutated to abolish binding to PS, were purchased from Nexins Research (Hoeven, The Netherlands).

To prove whether the regulation of HIF3α is due to direct binding of miR-210-3p miR-210-3p miR-210-3pget sites in the 3'UTR, the predicted binding sites were mutandd miR-485-5p miR-485-5p miR-485-5ponal file 1: Figure S1).

To abolish ERM binding without affecting the α-actinin binding site, only the first three key residues R, T and Y of the ERM binding motif were mutated to alanines.

Residues N71, Q104, and S192, which are located around the Pc binding site, were mutated to cysteine.

All residues from the predicted binding-region were mutated to Ala.

In conclusion, osmotin structure was predicted by homology modeling and IgE binding regions predicted were mutated to obtain a hypoallergenic protein.

coli) Elongation factor Tu (EF-Tu) that form the binding interface with aa-tRNA were mutated to alanine to better understand how modifying the thermodynamic properties of EF-Tu tRNA intEF-Tu tRNAan affect the decodinteractionies of the ribosome.

The ribosome binding sites (RBS) of the genes were mutated to adjust the expression level.