Finally, among Molecular Function terms, 'nucleotide binding'hydrolaseactivityvity' and 'RNA binding' were enriched in non-conserved gene-like sequences.
Our results showed that genes related to "purine nucleotide binding" and "nucleotide binding" were enriched in the targets of up-regulated miRNAs.
Gene ontology terms associated with mitochondrial functions (oxidation biological processes, monooxygenase and catalytic molecular functions, and iron, heme, and tetrapyyrole binding) were enriched in the significantly differentially expressed dataset.
In this study, we demonstrated that genomic regions harboring shared combinatorial TF binding were enriched in a tissue-specific manner for essential biological pathways, common DNA variants associated with complex traits, and regulatory DNA mutations associated with rare diseases.
Intriguingly, nearly half of these GO terms, for example, scaffold protein binding, were enriched in O-GlcNAc/Phos cross talk proteins, which corresponded to our results in GO enrichment analysis.
Moreover, we found that the GO terms "hydrolase activity, acting on acid anhydrides", "tetrapyrrole binding", "iron ion binding" and "heme binding" were enriched in the "molecular function" category (Additional files 11 and 14).
The GO term 'lipid binding' was enriched in both WD treatments.
For most ChIP-seq datasets, binding is enriched in the vicinity of the breakpoints near genes and enriched even more (p = 2.28⋅10-37) around breakpoints far from genes.
This is supported by the fact that 'metal-ion binding' is enriched in the core, as many metabolic enzymes have metal-binding catalytic centres.
By high-resolution mapping of intra- and interchromosome interactions, Rickman et al. [ 80] demonstrated that ERG binding is enriched in hotspots of differential chromatin interaction.
Categories "trans-membrane transporter activity", "substrate-specific transport activity" and to lesser extent "transferase-activity" and "nucleotide binding" are enriched in glumes.
