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These decreases in the level of binding were accompanied by similar decreases in the rate of selective uptake of HDL-CE (11 46% of that of wild-type SR-BI).
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In addition, MITF and c-FOS also bind to regions not bound in HPC7, and this "new" binding is accompanied by relocation of shared TFs such as GATA2 to these regions (see arrowhead in Fig 5A, right panel).
Calorimetric studies revealed that the binding was accompanied by a large positive entropy term with a small negative enthalpy contributions.
This zinc binding is accompanied by a large shift in the backbone conformation of the 99-loop and by large movements of both His side-chains.
Inhibitor binding is accompanied by a structuring of the region comprising residues Tyr71 Gly80 from being mostly disordered in the apoenzyme and leading to positioning of crucial active site residues for establishing enzyme inhibitor contacts.
The conventional thin section TEM thus confirmed that cell surface binding is accompanied by size changes of the core, but otherwise failed to reveal all other changes of the core seen by cryo-ET.
GTP binding is accompanied by conformational changes in both RF3 and the ribosome (Gao et al., 2007).
We conclude that POF binding is accompanied by HP1a binding at all POF enriched sites including the female specific PoX1 and PoX2.
When binding is accompanied by conformational changes in the protein, the change in conformation can precede or follow from the binding.
Its binding is accompanied by a distortion of the clathrin lattice, detected by a change in the axial ratio of the D6 barrel.
Combined NMR and MD analysis of PaDDAH showed that ligand binding was accompanied by a disorder-to-order transition for the L1 loop.
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