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In line with this binding, we uncovered a functional role for Nup98 in mediating enhancer-promoter looping at ecdysone-inducible genes.
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Furthermore we uncovered a lipid binding property which is mediated by a unique extended basic loop between blades 6 and 7 of the propeller.
To understand further the mechanisms that govern WTH3's differential expression, we uncovered a p53-binding site in its promoter, which indicated that WTH3 could be regulated by the p53 gene.
We uncovered a highly conserved OCT4 binding site within its proximal promoter and a significant decrease of the transcript level in OCT4 knockdown experiments [6], [9].
Using these data, we uncovered a new role for relocalized cytoplasmic poly(A) binding protein in repressing recruitment of TATA binding protein and RNA polymerase II to promoters.
By comparing E2F4 DNA-binding events among multiple primary tissues in human and mouse, we uncovered a conserved set of regulatory interactions potentially relevant to maintaining cellular quiescence.
We uncovered a strange pattern.
We uncover a striking enrichment within vertebrate CNEs for conserved binding-site motifs of the Pbx-Hox hetero-dimer.
Through global analysis of SOX10-binding sites and epigenetic characteristics of chromatin states, we uncover an extensive catalog of SOX10 targets genome-wide.
Our study is novel as we have uncovered a novel CaM binding protein, syt 7, as a key regulator of SV replenishment.
Here we identified Sac1 as a DVAP-binding protein and uncovered a hitherto unknown function of Sac1 in postembryonic synaptic maturation and neurodegeneration.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com