Sentence examples for binding we reasoned that from inspiring English sources
Given its influence on ligand binding, we reasoned that Trx1 might interfere with CD30-mediated signaling.
Because TRADD and RIP1 compete for TNFR1 binding, we reasoned that TRADD contributes to this switch to apoptosis upon RIP1 loss.
DOI: http://dx.doi.org/10.7554/eLife.03772.028 Since the activity of phosphorylated IGF1R-fl is high and unaffected by ligand binding, we reasoned that autophosphorylation must be the step controlled by ligand-dependent allostery.
Because mutants A1, B2 and D2 contained only single or double mutations that readily displayed high-affinity [H]granisetron binding, we reasoned that these subtle changes alone are sufficient to mimic the 5-HT3R-binding site.
To discriminate between these opposite binding modes, we reasoned that the reactive-site loop of the bound inhibitor would only be exposed in the ornithodorin-like conformation to allow targeting of a second serine proteinase.
By mutating the large residues found in the PFTase binding pocket, we reasoned that it should be possible to accommodate these larger analogues.
Due to enrichment of the acid-soluble proteome in nucleic acid binding factors, we reasoned that we should also find, within this particular proteome, deregulated factors capable of impacting gene/protein expression and contributing to malignant transformation.
If ZNF217 interacts with ERα and potentially contributes to the chromatin landscape associated with ERα binding, then we reasoned that ZNF217 expression might be higher in estrogen receptor positive (ER+) tumors.
Since agonist ligands are buried in the fold of the TR ligand binding domain (LBD), we reasoned that ligands that resemble agonists with large extensions should bind the LBD, but would prevent its folding into an active conformation.
Because a subset of human LAD borders is marked by an insulator element, the CTCF binding sequence [8], we reasoned that insulator proteins are likely candidates to be involved in modulating genome-NL interactions.
Because OLA1 blocks CHIP binding to HSP70, we reasoned that OLA1 might prevent CHIP from ubiquitinating HSP70.
