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The radiolabeling efficiency was 81.3%, and 64Cu binding was shown to be stable for 3 h.
Interestingly enough, collagen binding was shown to be essential for the virulence of Y. enterocolitica in mice inoculated intragastrically [28].
Because PKC ligand binding was shown to be dependent on phospholipid binding [32], it is perhaps not surprising that our method failed to predict PKC-delta as a druggable site since we do not treat the effects of membrane binding.
However, at the 6 week timepoint DAT binding was shown to be significantly reduced by 48% compared to levels in the EV condition (F2,18 = 5.61, P = 0.013; post-hoc, c.f. EV or GFP, both P<0.05) (Figure 6A).
Furthermore, Gremlin proteoglycan binding was shown to cause tyrosine phosphorylation of ERK1/2 in these systemic endothelial cells.
This direct binding was shown to be important in the anticancer activity of As2O3 in patients with acute promyelocytic leukemia (APL).
Similar(42)
The binding is shown to be negatively cooperative, with the cooperativity resulting from electrostatic interactions between the oppositely charged protein and polymer.
In this case, the corresponding kinetic paths of binding are shown to be intimately correlated with those of folding and the dynamics becomes quite cooperative.
Sialic acid binding is shown to trigger a conformational switch that modulates the affinity for the acceptor substrate and concomitantly creates the conditions for efficient transglycosylation.
Recently, RAR and ERα binding were shown to be highly coincident throughout the genome, competing for binding to the same or similar response elements [ 28].
Nine GO attributes were found to be significantly over-represented (Additional file 1), with calcium ion binding, structural constituent of muscle and actin binding being shown to be the most significantly over-represented GO terms.
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