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The low 11 C radioactivity in the white matter, where GlyT1 binding was reported to be high in in vitro ARG studies, was consistent with our previous ex vivo studies of 125I]IMPB [24] and previous PET studies with other GlyT1 ligands [19 21].
In preweanling animals, across all compounds and treatment protocols, QNB binding was reported to increase in six studies, decrease in two studies, and not change in four studies (Table 5).
A deletion of 2 bp in box B in vivo, which abolishes TFIIIC binding, was reported to result in rearrangement or destabilization of the nucleosomes in the gene-flanking regions [ 39], suggesting these nucleosomes in vivo are organized by TFIIIC-dependent chromatin remodeling.
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The N-terminus of GRP94 also contains a peptide binding site [13] and ATP binding is reported to dictate the conformation of the N-terminus and regulate its ability to form quaternary structural interactions [14], [15].
In addition, substrate binding is reported to occur through an induced-fit mechanism.
Second, CTCF binding is reported to mark boundary elements between neighboring genes [ 42].
Moreover, a Sos1 mutant, lacking four functionally important proline-rich (SH3 binding) regions was reported to be responsible for gingival fibromatosis [ 23].
The Nrd1 Nab3 heterodimer of RNA-binding proteins was reported to recruit the exosome to substrate RNAs (Arigo et al, 2006b; Thiebaut et al, 2006).
Certain antigens were found to have more diagnostic significance, one of them, 38 kDa antigen which is a phosphate-binding protein, was reported to be specific to the M. tuberculosis complex.
Δp53, which lacks a conserved domain of p53 in the DNA-binding domain, was reported to be transcriptionally active toward some p53 target genes and to be critical for the intra-S phase checkpoint (Rohaly et al, 2005).
The protein Poly (rC -binding prC -bindingCBprotein reported to bind the RNCMPT00044 motif [ 60] and appears to be multifunctional [ 61, 62].
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