While we agree that mutating the receptor-binding site on BLyS would have been a valuable way to address the importance of signalling through BLyS receptors, when these studies were carried out, the receptor-binding site on BLyS was not defined.
Dangerous was not defined.
One of the main shortcomings of simulating spherical particles is that the binding sites are not defined at fixed positions on the surface.
Besides integrins, periostin has been described to bind a number of other ECM proteins, for example heparin [ 37], fibronectin [ 38], and collagen I [ 35, 39], although the precise binding mechanisms are not defined in these cases.
Since substrate-binding specificity is not defined by the β-subunit in RabGGTase, it seems plausible that expression levels are at the root of these duplications.
However, the binding pattern of CTCF at −31 is not defined by a single peak of enrichment in ChIP-chip - it is likely to bind to several sites over at least 2 kb interval centered at −31.
The binding site of pateamine on eIF4A is not defined, although its activity is dependent on the nature of the linker region joining the amino-terminal (NTD) and carboxy-terminal domains (CTD), a region with significant sequence variation among DEAD-box family members [21].
Unfortunately, deservingness is not defined.
Distance itself is not defined.
However, variation in the abundance and function of CS/DS relative to tumor cell phenotypic properties and P-selectin binding are not well defined.
