STAT3 has a binding peak 14 bp upstream of the transcription start site (TSS) of JAK3, and this binding is much stronger (fold change = 12.47, FDR = 5.21 × 10−27) in the ABC subtype.
The situation was strikingly different, however, for CEBPB, PPARA, NR3C1/GR and FOXA2, binding of all of which was much stronger near CREB binding sites associated with the genes induced in response to fasting compared to all others, with the greatest differential observed for FOXA2.
The binding of all antibodies on T47D cells was much stronger than on MCF-7 cells.
Therefore the affinity of the single PIAS1 peptide for mono-SUMO2 (KD=16 μM) was much stronger than the binding of any RNF4-derived tandem SIM peptide.
This, said an EU lawyer, was much stronger, effectively meaning "a legally binding agreement".
In addition, it has been mentioned above that the phosphorylation of FUNDC1 Ser13 caused a ~3-fold reduction in the binding affinity of LC3B for FUNDC1 peptide (Fig. 1B), while the influence of the LC3B R10A mutation on the binding affinity is much stronger than that of FUNDC1 Ser13 phosphorylation.
Since the acceptors are in excess and binding to POPS is much stronger, the peptide, after dissociating from the donors into water, is most likely to bind to the acceptors.
Moreover, they also showed that FGFR binding to to FGF HSGAG complex is much stronger than FGFR binding to FGF2 alone [ 32].
