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We further confirmed that the binding was mediated by intact mode 3 motif (Figure 2B).
Moreover, the ILT4-specific antibody used for this study might have a partial overlap with ILT2 and we therefore cannot exclude that some of the tetramer binding was mediated by recognition of ILT2.
Although the ELISpot data indicated that MPER peptide binding was mediated by surface IgM, we examined whether gp41 MPER could interact with BALB/c B cells via other surface receptors such as Mannose C type Lectin Receptors (MCLRs; through which gp120 has been reported to interact with [38]).
In the cited study, the greatest effect on HNF4-specific binding was mediated by the E153D substitution, although the R161 presence seems to have an optimizing role.
We found that EAEC strain 042 has the ability to bind directly and indirectly to integrin α5 β1; direct binding was not mediated by AAF/II fimbriae and indirect binding was mediated by AAF/II and fibronectin.
Because the researchers found no mutations in the coding sequence of HER2 in the JIMT-1 cell line, they hypothesized that inhibition of trastuzumab binding was mediated by MUC4-induced masking of the trastuzumab-binding epitope [ 32].
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Finally, it has been shown that Dynein light chain (Ddlc) binds gurken mRNA in vitro and that such binding is mediated by the 3'UTR, not the GLS [40].
For E. coli, extensive studies have shown that membrane binding is mediated by MinD, which polymerizes and binds to the membrane in an ATP regulated fashion [6].
E6 proteins encoded by high-risk HPV types primarily bind to the tumour suppressor protein p53, and the binding is mediated by the E6-associated proteins (E6-AP).
This finding may not be unexpected as SAP97 has been shown to bind to 4.1R, another member of 4.1 family scaffolding proteins, and this binding is mediated by FERM domain, highly conserved in the 4.1 family [44], [45].
Zinc binding is mediated by two histidine and two aspartic acid residues.
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