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The GO term 'lipid binding' was enriched in both WD treatments.
In contrast, HIF binding was enriched in the vicinity of both mRNAs and lncRNAs (Fig 2A) with HIF-2 binding a slightly higher proportion of lncRNAs than HIF-1.
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Finally, among Molecular Function terms, 'nucleotide binding'hydrolaseactivityvity' and 'RNA binding' were enriched in non-conserved gene-like sequences.
For most ChIP-seq datasets, binding is enriched in the vicinity of the breakpoints near genes and enriched even more (p = 2.28⋅10-37) around breakpoints far from genes.
This is supported by the fact that 'metal-ion binding' is enriched in the core, as many metabolic enzymes have metal-binding catalytic centres.
Our results showed that genes related to "purine nucleotide binding" and "nucleotide binding" were enriched in the targets of up-regulated miRNAs.
By high-resolution mapping of intra- and interchromosome interactions, Rickman et al. [ 80] demonstrated that ERG binding is enriched in hotspots of differential chromatin interaction.
Categories "trans-membrane transporter activity", "substrate-specific transport activity" and to lesser extent "transferase-activity" and "nucleotide binding" are enriched in glumes.
Moreover, we found that the GO terms "hydrolase activity, acting on acid anhydrides", "tetrapyrrole binding", "iron ion binding" and "heme binding" were enriched in the "molecular function" category (Additional files 11 and 14).
In Cusanovich et al.'s paper [ 29], they reported that functional TF binding is enriched in the regulatory regions with a larger number of bound TFs and more binding sites.
In this study, we demonstrated that genomic regions harboring shared combinatorial TF binding were enriched in a tissue-specific manner for essential biological pathways, common DNA variants associated with complex traits, and regulatory DNA mutations associated with rare diseases.
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