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Given the regional binding values for both tracers ([18F]AV45 and [18F]AV1451) in all subjects using SRTM, it was possible to explore the correlations between [18F]AV45 and [18F]AV1451 uptake in different brain regions.
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High quality epitope maps were achieved by performing the assays at concentrations of soluble SA antibody fusions and antibodies that were equivalent to their KD binding values for the hCXCL1WT (2.5 nM for SA129, 100 nM for SA138, 1.5 μM for SA157*, 0.1 nM for Ab275, and 0.25 nM for Ab276).
In our case we had RNAP binding values for three distinct tissues: primary mouse keratinocytes, heart ventricle, and liver.
The end result was new "rotated binding values" for the promoters in each of the three tissues.
Differences between median binding values for each genotype were assessed by the Kruskal Wallis test with Dunn's multiple comparisons post-hoc test.
Gene binding values for MOF and H4K16ac from salivary glands were calculated by first extracting all data points (at 10 bp resolution) within annotated exons of each gene.
We also calculated gene binding values for MOF, MSL1, and MSL3 in S2 cells from data E-MEXP-1508 E-MEXP-1508 E-MEXP-1508et al. [ 29].
To calculate the amount of binding of different proteins at CBP sites, the top three consecutive binding values for each protein within 150 bp of the CBP peak centre was averaged.
Fusion of HSA to somatostatin-14 resulted in a 2.5-fold loss of activity for SSTR4 and an approximate 15-fold loss of activity for SSTR5, as measured by EC50 binding values for the various SSTRs [ 133].
To obtain comparable measurements among different centres, I-FP-CIT binding values for the caudate nucleus and putamen were calculated by means of the basal ganglia matching tool (Nobili et al., 2013).
While using binding data from 2 and 3 have yielded more acceptable binding values for 1 and a reasonable assessment of the 1·HSO4 – binding conformation, discrepancies with other complexes indicate that either more complicated equilibria are present or that cooperativity cannot be neglected in these systems.
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