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Just 1 to 2 days after their birth, AR are enriched in the following: alternative metabolism transcripts, which are responsible for the AR thriving in a hypoxic (<2% O2) environment; RNA binding transcripts, which may be involved in long-term RNA storage; and ribosomal protein transcripts, suggesting that AR boost translational capacity or build ribosomes with distinctive properties.
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The remaining unannotated transcripts (7,382) without homology to any protein may include non-protein coding transcripts, novel protein transcripts, rare transcripts that are expressed at low copies, transcripts with very low expression levels, or even transcripts which may have lethal functions in Escherichia coli.
To the end, we identified a group of aberrant transcripts which may be involved in SOD1 +/A272C -mediated pathogenesis of ALS.
And even then, polycistronic transcripts which may exist cannot be separated from chimeras perfectly [ 53].
Some genes possess multiple transcripts, which may have different TSS and/or TTS.
Furthermore, the analyses identified transcripts which may have responded to sympathoadrenal stimulation (e.g. GAL, GALP).
PduK58 has ten transcripts and PduM60 has five transcripts, which may suggest that these transcripts/proteins may be represented in similar proportions in these two populations.
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The other 15% mutations may impair substrate binding, which may indirectly still confer instability.
Of note, we have shown that MM-BMSC binding upregulate transcript levels of 26S proteasome subunits, which may serve to meet the increased demand for protein synthesis and protein degradation in MM cells.
The distribution of some polyadenylated transcripts varies in different tissues, which may indicate tissue-specific differences in the amount or specificity of transcript termination factors [26].
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CEO of Professional Science Editing for Scientists @ prosciediting.com