Sentence examples for binding to two distinct from inspiring English sources
Inhibition of ClC-ec1 occurs by binding to two distinct intracellular sites.
We unveiled the molecular details of antibody binding to two distinct protective epitopes within the NANP repeat.
On the other hand, the modest gains in binding affinity observed suggest that this ligand set has not yet found true bivalent interaction with the M6P/IGF2R (i.e., simultaneous binding to two distinct M6P-binding pockets).
SimR is known to repress expression of simX and its own gene by binding to two distinct operators within the simR/simX intergenic region Le et al. 2009.
We found that apical recruitment of Dia is mediated by binding to two distinct elements, PI 4,5 P2 and Rho1.
Trimeric TNF, mostly produced by activated macrophages and T cells, acts by binding to two distinct TNF receptors: TNF-RI (p55), which is widely expressed; and TNF-RII (p75), mostly present on cells of the immune system.
- Intracellular stores of TRAIL have also been found in polymorphonuclear neutrophils - that are released after a variety of stimuli.,, At physiological conditions, TRAIL is capable of binding to four distinct transmembrane receptors in humans: the proapoptotic death receptors DR4 and DR5 or the two decoy receptors DcR1 and DcR2.
After being cleaved at a site proximal to the transmembrane domain of TNF-α by TNF-α converting enzyme, a soluble trimeric form of TNF-α is released and exerts its activity by binding to two structurally distinct type I and type II TNF receptors (TNFRI and TNFRII) on effector cells.
TNF mediates various cellular responses by binding to two structurally distinct receptors: TNF receptor 1 (TNFR1; TNFRSF1A, CD120a, and p55) and TNF receptor 2 (TNFR2; TNFRSF1B, CD120b, and p75), members of the TNFR superfamily [ 4, 5].
In accordance with the SEC results, we fit the fluorescence anisotropy data to a model in which two molecules of FIR bind sequentially to two distinct binding sites on FUSE.
Chromatin immunoprecipitation assays showed binding of COUP-TFII to two distinct regions of the Snail1 promoter harbouring COUP-TFII-binding sites.
