Sentence examples for binding to tissue proteins from inspiring English sources

Somewhat more complicated methods thought to reduce Ab binding to tissue proteins include using diluent buffers with low ionic strength, and adding non-ionic detergents (such as Tween 20 or Triton X) or ethylene glycol to the diluent15,16.

Likewise, non-specific Ab binding to tissue proteins due to hydrophobic interaction between proteins or ionic and electrostatic interactions does not take place in routinely fixed cell and tissue samples.

Binding to tissue proteins contributes to a large volume of distribution and long terminal half-life.

29 30 IBP shows strong binding to plasma albumin and low binding to tissue proteins such as actin; as a consequence, IBP has a low volume of distribution of around 0.1 0.2 L/kg.

After intravenous injection, the drug is released rapidly and quantitatively from the complex upon dilution, followed by competitive replacement and binding to tissue and plasma proteins.

Vinyl chloride, trichloroethylene, and carbon tetrachloride showed irreversible binding of metabolites to tissue proteins, mainly of the liver.

The degree of stereo selectivity in binding to plasma or tissue proteins, which is species dependent, may result in a significant effect on the amount of drug in the plasma [ 36].

CKD affects thyroid function in many ways, including low circulating thyroid hormone levels, altered peripheral hormone metabolism, insufficient binding to carrier proteins, reduced tissue thyroid hormone content and altered iodine storage in the thyroid gland.

The pharmacology of pentamidine presents various difficulties including extensive tissue retention and binding to serum proteins giving a large volume of distribution and long-terminal half-life, while little drug can enter the brain.

The fact that volume of distribution of tacrolimus appeared to be closer related to fat-free mass than to total body weight indicates that the extent of tissue distribution of tacrolimus may be determined mainly by binding to proteins in lean tissues.

Importantly there was no non-specific binding to muscle tissue where titin (a protein with the nearest sequence to IQ-tag) is expressed abundantly.