Sentence examples for binding to this enzyme from inspiring English sources
Increased NADP+ activates G6PD by competing with NADPH for binding to this enzyme.
Furthermore, we found that NADP+, which is known to activate G6PD by competing with NADPH for binding to this enzyme, plays a role in stabilizing G6PD dimers by blocking the p53-G6PD interaction (Jiang et al., 2011).
The test set consists of 38 inhibitors of factor Xa with good binding energies and 26 molecules that have not shown binding to this enzyme in experiments.
Postulations have also been made to employ β-aminopropionitrile, a compound that inhibits enzymatic activity of lysyl oxidase by irreversible binding to this enzyme [ 38, 39].
Interestingly, SN34452 largely retains its potency against PI4K TypeIIIβ (Table 2), which indicates the carboxamide is not critical for binding to this enzyme.
The D12A/D66A enzyme displays a level of binding discrimination against rNTP similar to the wild-type enzyme; the Kd for rNTP binding to the D12A/D66A enzyme is ∼700-fold larger than the Kd for dNTP binding to this enzyme (Table 1).
This improved both binding to the enzyme and physiochemical properties without compromising ligand efficiency.
This analysis suggests that cooperative binding to the enzyme is largely the result of the high preferential affinity of ligands for the R state.
Glucose acts as an inhibitor by competing with the substrate in binding to the enzyme (Fang et al. 2010).
