Sentence examples for binding to this coreceptor from inspiring English sources

For example, people with the CCR5-Δ32 mutareon aresistantantoto infection with R5 virus, as the mutation stops HIV from binding to this coreceptor, reducing its ability to infect target cells.

Recent studies have provided new insights into the factors the trigger translocation of BoNT/B and revealed that this serotype requires both binding to the coreceptor molecule GT1b and low pH to transform into an oligomeric membrane protein.

Binding of gp120 to CD4 triggers conformational changes responsible for binding to the coreceptor.

The biologic effects of VEGF are mediated through binding to one of three endothelial surface receptors VEGF-R1 (flt-1), VEGF-R2 (flk-1/kdr), VEGF-R3; binding to the coreceptor neurophilin enhances signaling [ 9, 10].

It was found that BoNT/B is a coincidence detector: binding to the coreceptor molecule, the ganglioside GT1b, allows the toxin to sense low pH and transform into oligomeric hydrophobic membrane-associated channels.

Wnts mediate these effects by binding to a conserved coreceptor complex and activating one of several downstream signaling cascades.

Park et al identified PEDF's ability to inhibit Wnt/ β-catenin signaling in the eye with avid binding to the Wnt coreceptor, low-density lipoprotein receptor-related protein 6 (LRP6).

HIV-1 binding to the chemokine coreceptor CXCR4 initiates chemotactic signaling, mimicking chemokine-induced actin dynamics to facilitate infection processes such as entry, early DNA synthesis, and nuclear migration.

Wnt binding to Wnt coreceptors LRP5 and Frizzled leads to the inhibition of glycogen synthase kinase-3 β (GSK-3 β), leading to decreased β-catenin phosphorylation and prevention of its proteasomal degradation.

We tested this possibility by treating TZM-bl cells with blocking antibodies and small molecules that prevent HIV infection by binding to CD4 and coreceptors CXCR4 and CCR5.

However, these coreceptor binding epitopes in gp120 on the virions during the natural infection process are unlikely to elicit immune responses based on steric hindrance and time limitation because exposure of these epitopes (from gp120-binding to CD4 to gp120-binding to a coreceptor) to the immune system is very limited.