Sentence examples for binding to this complex from inspiring English sources

It appears that soluble EPCR binding to this complex results in inhibition of tight neutrophil adhesion.

Ligand binding to this complex leads to recruitment of the intracellular adaptor proteins and activation of the transcription factors, NF kappa B, AP-1, and C/EBP.

NO can compete with O2 for binding to this complex and thereby inhibit respiration but higher concentrations are needed than to activate receptors, the EC50 value at physiological O2 concentrations (20 30 μ m) being 120 n m (Bellamy et al., 2002).

Inhibitors of cyclin/Cdk complexes, by binding to these complexes, negatively regulate cell cycle progression [ 2].

The binding of VWF to this complex facilitates the activation and aggregation of platelets and the interaction of platelets with components such as collagen in the damaged vessel lining.

Consistent with the assignment of τD3 to A3AR ligand complexes, the binding of CA200645 to this complex could be potently antagonized by nanomolar concentrations of A3AR antagonists such as MRS 1220.

Up stream caspases are activated when more enzyme molecules are brought in close proximity and undergo conformational changes upon binding to activation complexes, this results in their cleavage and full activation [ 5, 6].

To assess the inhibitory interactions of AIP4 directly, we purified the PRR/WWI-IV region and the HECT domain of AIP4 and used the intermolecular PRR/WW-HECT complex to mimic the autoinhibited state of AIP4; then we examined whether spartin's binding to AIP4 disrupts this complex.

The loss of H3K27me3 observed here could be explained by dilution of a limited amount of PRC2, due to the increased binding of this complex to numerous intergenic sites uncovered by loss of DNA methylation 35.

> -wrap-foot> > -wrap-foot> The mTOR inhibitor rapamycin and its analogs bind FK506 binding protein, and this complex binds to mTORC1, inhibiting downstream signaling [ 30].

The mTOR inhibitor rapamycin and its analogs bind FK506 binding protein, and this complex binds to mTORC1, inhibiting downstream signaling [ 30 ]. Everolimus and temsirolimus are rapamycin derivatives that have been evaluated in the treatment NET (Tables  1 and 2 ).