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After binding to this cell-surface receptor, DT is endocytosed and trafficked to an acidic vesicular compartment, where it undergoes a pH-dependent conformational change, cleavage and release of the catalytic domain.
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EGF binding to the cell-surface EGF receptor (EGFR) triggers EGF EGFR trafficking to the ER.
In both cases, chemokines provide a chemotactic signal to cells by binding to their specific cell-surface receptors.
Their binding to glycans of cell-surface glycoconjugates can also trigger intracellular activity.
Consistent with PTD uptake, extracellular PrP binding to the cell surface could be competed with soluble GAGs.
These agents can function by binding to the cell surface and may utilize ADCC, complement activation, or cellular apoptosis.
The three Hh ligands (Sonic, Indian and Desert) activate pathway signaling by binding to the cell surface receptor Patched (PTCH).
VSV particles enter cells through surface glycoprotein G mediated binding to the cell surface, endocytosis, and membrane fusion [36], [37].
CSPG4 is critical for TcdB binding to the cell surface, inducing cytoskeleton disruption and cell death.
A previous study showed that CCL3 affects cell migration through binding to the cell surface CCR5 receptor [ 28].
They exert their effects by binding to the cell surface receptors ETA and ETB [ 39].
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