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The same approach was followed to identify mutations hindering AP-1 binding to the AP-1#2 and AP-1#3 sites of fragment 5103 and to demonstrate their ability to abolish in vitro AP-1 binding to their respective sites (Figures 3A and 3B, respectively).
Most of the antibodies showed specific binding to their respective overexpressing cell line but not to the non-transfected cells, thus indicating binding to their respective target receptor.
We also show that the protein-modified Au films exhibit measurable SPR shifts upon binding to their respective target ligands.
These factors may exert their cytoprotective effects by binding to their respective receptors on cardiomyocytes and/or other surrounding cells.
The Wnt signaling is initiated by extracellular proteins, i.e., Wnts, through binding to their respective frizzled family of receptors.
One explanation to be considered is that BPA may act via ERα through mechanisms other than binding to ERE, through other transcription factors binding to their respective response elements [42].
Similar(19)
A general question is how motors search for sites in the cell where both motor ends can bind to their respective binding partners.
To investigate the effect of binding of the ions and the substrate on protein dynamics, one would ideally design and perform equilibrium MD simulations of the protein in the presence of these species initially placed in the bulk and monitor their movement over time as they diffuse, find, and bind to their respective binding sites.
In cell-based assays employing intermolecular FRET interaction, the fluorophore pairs are typically conjugated to soluble ligands, e.g., EGF, transferrin and others, that can come into nanometer-range FRET proximity upon binding to their dimerized/oligomerized respective receptors.
Although, in the control experiments, only Gnps did not show any bactericidal activity (Fig. 6) so the antibiotics conjugated with Gnps might have a higher binding affinity to their respective targets.
To confirm the direct effects of these miRNAs, we fused the 3′UTR sequences of FOXO3, BMI1 and E2F1, each containing putative binding sites to their respective miRNA, to a luciferase reporter gene.
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binding to their postsynaptic
binding to their 'category-I'
binding to their natural
binding to their immobilized
binding to their mutual
binding to their regulatory
binding to their α2δ
binding to their common
binding to their cognate
binding to their associated
binding to their specific
applicable to their respective
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