Sentence examples for binding to the wild-type from inspiring English sources

GCs exert their effects by binding to the wild-type GR, GRα.

Among the six mutations tested, five of them reduced the binding of -crebanine (1) by more than 40% relative to binding to the wild-type receptor, displaying the importance of hydrophobic interactions.

Combined with mutation analysis and molecular dynamics simulations with apelin-13 binding to the wild-type APJR, this structure provides a mechanistic understanding of apelin recognition and binding specificity.

Additionally, a non-extendable primer with more mismatches to the mutant allele than to the wild-type allele (blocker primer, BP) competes with the MSP for binding to the wild-type allele, thereby reducing background amplification from the wild-type allele.

It is of interest that dsDNA binding to the wild-type SsoRadA protein saturated at ∼one protein per bp.

We validated Trim25 binding to the wild-type pre-let-7a-1 and pre-let-7a-1@2 mutant by RNA pull-down followed by western blotting.

Binding of hEBV321 to VEGF-G88A resembled its binding to the wild type VEGF, but binding of Bevacizumab to VEGF-G88A was substantially reduced as compared to hEBV321 (Figure 3D).

In comparing to proteins binding to the wild type eIF5B, several proteins were found to preferentially bind to eIF5B-S214E mutant, but not eIF5B-S214A mutast as displayed in Fig. 2C.

Here we used structural and biophysical approaches to characterize genistein binding to the wild type (TTRwt) and to its most frequent amyloidogenic variant, the V30M mutant.

Furthermore, we could also identify potential allosteric movements caused by genistein binding to the wild type TTR that explains, at least in part, the frequently observed negatively cooperative process between the two sites of TTRwt when binding ligands.

In vitro affinity measurements of Hfq for RydC show similar binding to the wild type.