Sentence examples for binding to the variant from inspiring English sources

For the PARP1 rSNP79 SNP, miR-145 binding was predicted to have the greatest ΔΔG (−5.71 kJ/mol), with the variant C allele ΔG being less negative than the wild-type T allele ΔG (Table I, a similar profile to that of two of the other three miRNAs predicted to bind this site) suggesting a decreased miR-145 binding to the variant PARP1 mRNA 3′UTR and thus increased PARP1 expression.

The reduction in RUNX1 binding to the variant 1 sequence was confirmed by electrophoretic mobility shift assay (EMSA) (Fig. 2).

Development of a novel probe for measuring drug binding to the F1*S variant of human alpha 1-acid glycoprotein.

As shown in Fig. 5, mutations of the Ca2+-coordinating residues (D1139A and N1210A) abolished binding to the B- variant of NL1 (lanes 2 and 3).

Intriguingly, both MtNup188 and MtNup192 were strongly enriched on all wild-type FG-repeat regions and did not show significant binding to the Nup116 348 458 10xFA variant.

One obvious conclusion can be drawn from these results: the putrescine binding to the D174N variant does not show any significant heat effect, strongly suggesting that AdoMetDC-D174N is no longer able to bind putrescine.

To identify the TFs involved in binding to the LPL variants, which also conferred differential expression in luciferase reporter assays, competition assays were carried out using MC-EMSAs (15).

Co-precipitation of FLAG-Rab26WT was observed with EGFP-Rab26 WT and even more efficiently with the GDP-preferring variant Rab26TN whereas co-precipitation with the nucleotide-empty variant (Rab26NI) was reduced and binding to the GTP-preferring variant (Rab26QL) was abolished.

The semi-quantitative surface-binding immunoblot (SBI) assay, which utilizes whole gonococci, was used to compare the concentration of antibodies needed for detectable binding to the different Opa variants of strain FA1090.

Larson, H. N. et al. Structural and functional consequences of coenzyme binding to the inactive asian variant of mitochondrial aldehyde dehydrogenase: roles of residues 475 and 487.

We created a new DNA recognition specificity for tetracycline repressor (TetR) binding to the tet operator variant tetO-4C5G containing four bp exchanges compared to tetO.