Sentence examples for binding to the unfolded from inspiring English sources
Accumulation of unfolded proteins leads to release of BiP from the ER stress sensors and subsequent binding to the unfolded proteins [1].
These results indicate that a protein fold can have a remarkably broad potential for accommodating metal-mediated cross-links and suggest strategies for engineering protein stability by constructing metal sites that maximize metal binding to the native state and minimize binding to the unfolded state.
We provide evidence consistent with a mechanism of action for HNK that includes binding to the unfolded ATPase domain of GRP78 with a consequent induction of ER stress.
The greater effectiveness of HNK at inducing ER stress was consistent with DSC data indicating greater efficacy of HNK for binding to the unfolded ATPase domain.
Important considerations for designing metal-binding sites are that packing interactions in the binding site should be carefully considered to avoid costly reorganization energies and binding to the unfolded stable should be destabilized (negative design).
Thermodynamic analysis revealed that all variants bound metal to the unfolded state, and the observed metal-mediated stability is a consequence of differential binding to the folded native state and unfolded structures, although the dominant factor for binding to the unfolded state is unclear.
Metal-mediated stability is the consequence of differential binding to the native and unfolded states.
In contrast to HSP47, most other chaperones destabilize native proteins by preferential binding to unfolded, partially unfolded, and misfolded polypeptide chains.
Unfolded protein binding to the Ire1-LDs leads to Ire1 oligomerization in foci.
The accumulation of unfolded proteins titrates Grp78/BiP from binding to the luminal tails of the ER transmembrane proteins PRK-like ER kinase (PERK), inositol-requiring transmembrane kinase/endonuclease (IRE-1) and activating transcription factor 6 (ATF6).
UP1 clearly exhibits preferential binding to the G-quadruplex structure as compared with its binding to unfolded or unstructured DNA.
