Sentence examples for binding to the top from inspiring English sources

Like other Top 1 inhibitors it exerts its mechanism of action through binding to the Top 1-DNA complex during replication and transcription and thereby maintaining single-strand DNA breaks, ultimately resulting in the formation of double-stranded DNA breaks, which causes cell death [ 24].

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The next step is the superimposition (and subsequent ligand transposition) of the query binding site to the top scoring target binding sites.

On going from the initial to the second transition states, the N 2p state shifted continuously towards lower binding energy to the top of the valence band, while the O 2p state shifted to lower binding energy up to the first transition state and then shifted to higher binding energy after the first transition state.

Conjugating PS 1 and PS 2 to MAb 35A7 and FSP 77 resulted in slightly diminished binding to the SKOv3-CEA-1B9 cell line (top four histograms), although the conjugates displayed positive binding with respect to the irrelevant control.

Ørom et al. (2008) have reported that mir-10a has a positive effect on general protein translation by binding to the 5′-UTR of ribosomal 5′ TOP (terminal oligopyrimidine) mRNAs and enhancing their translation.

Most of binding residues for the top three compounds were below 0.5, suggesting that the structure of ApoE4 will not affect ligands binding to the active site.

Valence band maximum (Ev) is the binding energy corresponding to the top of the valence band (VB) for Si and LaAlO3, respectively.

With moxifloxacin, the top 20 binding poses were similar to the top 20 binding poses generated using wild-type enzyme, as expected from moxifloxacin lacking a contact with GyrB-Glu466.

We failed to show binding to top sites in the promoters of SAC3D1 and PPM1G (Figure 4A).

The binding buffer was allowed to drain to the top of the column bed before loading the column with the prepared extract.