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DNA footprinting analysis further demonstrated the specificity of PNAs binding to the targets.
It is known that TFs regulate their direct targets by binding to the targets' promoters and regulate their indirect targets by transcriptional regulatory chains through intermediate TFs [ 6, 7].
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Positron emission tomography, or PET, can be used to tell if a drug is binding to the target protein in the body.
To improve access and binding to the target we have now designed novel N10,N11-di-alkylamine N10,N11-di-alkylamine N10,N11-di-alkylamine
Likewise, bivalent binding to the target may negatively influence the therapeutic efficacy of an antibody.
Most of the drug molecules exhibit their biological activity through binding to the target protein.
In these organisms, the inhibitory mechanism involves binding to the target proteins, collectively named Target of Rapamycin (TOR) [12].
The addition of strept-AuNPs, binding to the target due to the strong streptavidin biotin interaction, led to a further increment of Rct thus obtaining significant signal amplification.
The membranes were probed separately to evaluate MAb versus scFv binding to the target antigen in cell lysates.
These results suggested that miRNA recruited eIF4E2 to compete with eIF4E1 for binding to the target mRNA.
This option allows to enforce certain interactions that are critical for ligand binding to the target protein of interest.
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