Sentence examples for binding to the substrate from inspiring English sources
This suggests that the peptide might bind to the active site of ACE to block it from binding to the substrate.
In this way, CUL3 acts as an active scaffold to direct ubiquitylation, as C-terminally bound RBX1 binds ubiquitin-conjugating E2 enzymes that are charged with ubiquitin, while simultaneously binding to the substrate adaptor, in this instance KLHL3.
When the mixture was applied to a substrate, the PMMA formed a strong composite with the MWCNTs, while strongly binding to the substrate.
Two types of surfaces with different polymer chains binding to the substrate were prepared and its ability to reduce the protein adsorption was compared.
This report examines the tether design (e.g., extent of functionalization) and cationic polymer structure for their effect on complex binding to the substrate and cellular transfection.
In the absence of crystal structure, our study provides an early insight into the structure of CS from Shigella flexneri and its binding to the substrate and cofactor, thus facilitating the inhibitor design.
The acquired plasticity may constitute a gain of function as it would allow multiple induced conformations upon binding to the substrates, improving the binding diversity [29], [30].
Recent studies have shown that tyrosine kinase inhibitors inhibit ABC transporters by binding to the substrate-binding sites within the transmembrane domain at clinically achievable concentrations [45], [48].
The analysis of the active cleft shows that the helix at the substrate binding groove provides a platform for the stable binding to the longer substrate, explaining the substrate specificity of TreX.
The mutant domain showed significantly decreased binding to all DNA substrates and complete loss of preferential binding to the unmethylated substrate in vitro (Figure 2B).
In addition, a subset of Aβ42-lowering non-steriodal anti-inflammatory drugs [17], [18] act as γ-secretase modulators (GSMs) indirectly via binding to the APP substrate [19].
