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On the other hand, the polymer moiety does not mask the oligonucleotide part from its binding to the strong anion-exchange support, and the different chains are efficiently separated on the basis of their charge.
SNPs with a ratio significantly greater (P < 0.05, Fisher's exact test) than four (the value of four being the ratio of binding to the strong C/ motif vs. the weak /G motif) are more deleterious to binding in the context of the weaker (/G) motif.
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The hydrophobic interaction between the Met181 residues and the fullerene surface is the main cause of the strong binding to the NavAb channel.
The addition of strept-AuNPs, binding to the target due to the strong streptavidin biotin interaction, led to a further increment of Rct thus obtaining significant signal amplification.
It can be assumed that the toxicity of NPs within the fabric is much less compared to that of other carriers due to the strong binding to the tissue structure, while maintaining availability for microorganisms.
Thus, it seems that while the evolutionary pressure for binding to the SH3 domain is strong, the precise mechanism of binding can vary.
The base pairs flanking the mismatch had weak effect on the binding, with showing the strongest binding to the A A mismatch in the CAG/CAG sequence.
ChIP assays of mouse primary keratinocytes under growing conditions demonstrated p63 binding to the corresponding mouse sequences, the strongest binding region being the +1.8 kb region from the Fgfr2 transcriptional start site (TSS) (Fig 4D; Supporting Information Fig S7B).
In contrast, the heme mimetic BAY 58-2667 (1), whish is known to bind to the heme domain, showed strong binding to the full length sGC and only non-specific binding to sGCcat, as per analysis of the sensorgrams (see Supplementary information).
Neither xDsh nor mPer1 showed strong binding to the chimeric protein, compared to CKIε (Fig. 6A).
5'-OCQA exhibits strong binding to the glycerol-3-phosphate transporter (see Table 6 and Figure 5, A).
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