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This enhanced cell death, specifically induced upon antigen binding to the specific B cell receptor, is caused by an increased activation of c-Jun NH2-terminal protein kinase and Bim [ 21].
CARs are genetically engineered receptors that could stimulate tumor cytotoxicity once binding to the specific tumor epitopes.
The development of the compounds preferentially binding to the specific DNA sequence is one of the potential but very difficult approaches in this strategy.
The genuine strength of this powerful molecular imaging modality is its picomolar sensitivity and the possibility of quantitative imaging of in vivo binding to the specific neuroreceptors like TSPO, dopamine receptors and serotonin receptors.
The goal of endocrine therapy in breast cancer is to block the action of estrogen on the tumor cells either by inhibiting estrogen from binding to the specific estrogen receptor or by inhibiting its synthesis.
This high sequence homology found in CDRs of VH or VL of these mAbs contributes to our better understanding and determination of binding to the specific antigenic epitope(s).
Similar(26)
By analyzing the results of phage-ELISA (Figure 2B), 30 phage clones specifically binding to the BCG-specific γδ T cells (the ratio of specific binding to nonspecific binding was more than 2) were amplified by RT-PCR (Figure 2C).
Here we propose that binding to the ubiquitin specific protease, USP7, is yet another means of regulating this property of p53.
KIG31-1 competes with activated PKCγ for binding to the isoenzyme-specific docking proteins, receptors for activated C kinase.
It acts as a splicing activator in dsx pre-mRNA splicing (its binding to the female-specific exon promotes the inclusion of this exon into the mature mRNA), and as a splicing inhibitor in tra pre-mRNA splicing (its binding to the male-specific exons prevents the inclusion of these exons into the mature mRNA).
Both Ang-1 and Ang-2 act by binding to the endothelium-specific receptor tyrosine kinase 2 (Tie-2).
More suggestions(15)
binding to the active
binding to the mammalian
binding to the upper
binding to the bacterial
binding to the AMP-lid
binding to the imprinted
binding to the degenerate
binding to the wild-type
binding to the cellular
binding to the extracellular
binding to the hydroxyapatite
binding to the 16-base
binding to the human
binding to the nucleobase
binding to the urinary
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