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Directly, RNAIII down regulates expression of Protein A by binding to the spa mRNA [12].
As illustrated in Fig. 1, Rot activates spa transcription directly by binding to the spa promoter, and additionally, by enhancing transcription of sarS, encoded directly upstream of spa [11,13].
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Collectively these results suggest that SpA binding to the osteoblasts is responsible for RANKL expression leading to activation of osteoclasts and bone breakdown.
These results suggest that SpA maybe binding to the osteoblast TNFR-1, however additional experiments using TNFR-1 null mice or siRNA to reduce the receptor are required to confirm this.
This is likely to be caused by antibody binding to the surface-expressed S. aureus immunoglobulin binding protein, Spa.
Take me to the spa.
4. Send her to the spa.
Go to the spa.
Go to the spa and get pampered.
Arrive to the spa on time.
Go to the spa or the gym.
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