Sentence examples for binding to the single from inspiring English sources

EE can be useful for converting the K d predicted for binding to the single best binding site into the overall binding, allowing for pose flexibility.

In addition, RBD mutations have been used to demonstrate that input of RAS binding to the single Drosophila type I PI3K is critical in insulin-pathway-controlled developmental growth (Orme et al., 2006) and that RAS binding is required for PI3K activation by chemoattractants in Dictyostelium (Funamoto et al., 2002).

In contrast, telomestatin (up to 10 µM) had no effect on Topo III binding to the single-stranded oligonucleotide S310 (Figure 2B).

However, the association between RPA and the single-stranded DNA prevents RAD51 from binding to the single-stranded DNA and hence its recombinase functions.

Instead, persistent DNA 5′ end resection is likely due to the roadblock in the HR pathway that is created by the failure of RAD51 binding to the single-stranded DNA.

Interestingly, cold shock proteins and DBRHs have been suggested to work together, with helicases opening double-stranded structures and cold shock proteins binding to the single-stranded end products, their combined activities preventing the formation of unfavourable structures (Hunger et al., 2006).

Our experiments revealed that D1R-MIP sensors are useful for estimating the strength of ligand binding to the active single site.

On the one hand, the improvement effect of the QDs to the specificity of the PCR could be attributed to the similar optimization mechanism of the single-stranded binding protein (SSB), which selectively binds to the single-stranded DNA rather than double-stranded DNA and then minimizes the mispairing between the primers and the templates in the PCR system [6, 24].

Telomeres are associated with proteins, both binding to the duplex and single-stranded telomeric sequences.

This result signifies that PA analogs inhibit HIV-1 fusion by binding to the CD4 receptor as a single molecule, and not in the form of micelles that exist at higher micromolar concentrations.

Noting that half-maximal elongation rates are already achieved at relatively low tetramer concentrations (∼25 50 nM), we estimate by assuming an on-rate constant of ∼20 μM−1 s−1 for VASP binding to the barbed end that a single VASP tetramer might be processively associated with the filament end for ∼1 2 s.