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After binding to the respective receptor at the ciliated surface, the viruses are internalized and delivered into early endosomes.
In molecular imaging, the development of suitable radiolabeled probes requires a rational design based on the structure biological activity biodistribution relationship because the requirement of structural specificity for a radiolabeled probe is rigidity for binding to the respective DNA, mRNA, receptor, transporter and enzyme.
We are interested in the control aspect: some proteins, called Transcription Factors, possess the ability to regulate the expression of genes by binding to the respective promoter regions on the DNA and thereby influencing their transcription processes.
Furthermore, protamine activated channels at low resting cytosolic Ca2+ levels (25 100 nM) even in the absence of lumenal Ca2+ or in the presence of high cytosolic Mg2+ levels, suggesting that protamine-induced RyR2 activation mainly results from electrostatic interactions and does not seem to require cytosolic or luminal Ca2+ binding to the respective activating sites.
On the one hand, regulation of cluster III and V genes by CbfA may not involve any direct binding to the respective gene promoters, but instead require protein interactions in multiprotein transcription complexes that cannot be accessed by isolated CbfA-CTD.
These data highlight the importance of the mutated residues for the binding to the respective partner.
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After autoantibody-binding to the respective myocardial antigen via the F ab 2 part and cross-linking via the Fc part to Fcγ receptors IIa, these receptors then may induce an activating signal via the FC receptor's cytoplasmic domain, thereby possibly triggering a cardiodepressive effect (see Figure 1I).
Integrins signal through the cell in either direction: the extracellular binding activity of integrins is regulated from within the cell (inside-out signaling), whereas the binding to the ECM or the respective cellular counter-receptor elicits signals that are transmitted into the cell (outside-in signaling) (Hynes, 2002).
The best neo-epitope-MHC pair was defined as the peptide which has the strongest predicted binding affinity to the respective MHC allele.
These mimotopes had similar relative binding affinity to the respective MHC molecule however formed higher affinity interactions with CT-TCR which recognize the wild-type peptide.
Recently, it has been shown that miRNAs are well recognized as gene regulators via binding to the 3'-untranslated regions of their respective targets protein coding transcript.
More suggestions(15)
binding to the two
binding to the their
binding to the alveolar
binding to the heterodimeric
binding to the active
binding to the mammalian
binding to the bacterial
binding to the antibody-bead
binding to the AMP-lid
binding to the imprinted
binding to the degenerate
binding to the Smad
binding to the hydroxyapatite
binding to the regulatory
binding to the nucleobase
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