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In the presence of target protein, its binding to the recognition elements linked onto the Hp2 scaffold endows the steric strain to open the Hp2 stem, propagated by the disruption of the kissing complex structure, resulting into a decreased electrochemical signal related with the protein quantification.
However, upon binding to the recognition DNA sequence, the Pax-6 folds and displays CD spectroscopic evidence of significant α-helical structure [ 129].
While binding to the recognition site requires a highly conserved protein structure, the regulatory function obviously tolerates a higher sequence variation.
This standard can be titrated to generate a consistent PCR signal across different numbers of cycles by altering the ratio of 18S primers and competimers, the latter of which inhibit primer binding to the recognition sequence.
T3/T4 binding to the recognition site of integrin αv β3 activates PI3K, stimulating shuttling of TR β1 from the cytoplasm to the nucleus and increasing expression of target genes such as hypoxia inducible factor-1 α (HIF-1 α) [ 58].
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Four residues found to bind urate in HucR (W11, D56, R63, and R89) and communicating ligand binding to the DNA recognition helices are predicted to occupy the same position in the model of MftR (shown in red in Figure 3).
NF-κB activation following RSV-antigen binding to the pathogen recognition receptors TLR 4 or RIG-1 is a primary stage in the immunological response to RSV [ 29].
Interestingly, a KGD sequence can be found within the extracellular domain of the CD154 molecule, thereby allowing binding to the KGD recognition motif of αIIbβ3.
In Arabidopsis, ICE1 acts directly upstream of the CBFs by binding to the MYC recognition sites present in the promoters of the CBF genes, and this binding subsequently triggers the expression of the CBFs/DREBs regulon [ 9, 27].
In Arabidopsis and wheat, ICE1 acts directly upstream of CBFs by binding to the MYC recognition sites present in CBF gene promoters, and then subsequently triggers expression of CBF/DREB regulons [ 1, 45].
Arsenic could be directly binding to the sRAGE, inhibiting recognition by the antibodies used in the ELISA.
More suggestions(15)
binding to the cue
binding to the yeast
binding to the waaA
binding to the γδ
binding to the lipid
binding to the brain
binding to the a7-nAChR
binding to the promoter
binding to the soil
binding to the spa
binding to the receptor
binding to the sugar
binding to the gold
binding to the reference
applicable to the recognition
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