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Upon binding to the receptors, galectin-4 could promote partly the dedifferentiation and proliferation of OLGs (Stancic et al., 2012).
Ethanolamine class of H1 antihistamines were proven to show stereoselectivity in binding to the receptors (Casy et al. 1992).
The relative dissociation constant of BtA to Bt toxin was only 29% for the binding to the receptors.
Further, the bispecific antibodies were comparable to their parent antibodies in their potency in blocking ligand binding to the receptors and in inhibiting ligand-induced biological activities.
It is clear that each pharmacophoric group, the butyrophenone, the piperidine and the 4-chlorophenyl moieties contributes to changes in binding to the receptors of interest.
Compared to the bispecific/divalent diabody, the tetravalent di-diabody binds more efficiently to both of its target antigens and is more efficacious in blocking ligand binding to the receptors.
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The drugs, which in general are proteins known as monoclonal antibodies, block PCSK9 from binding to the receptor.
By binding to the receptor, drugs either enhance or inhibit its activity.
The two most common are binding to the ligand-binding site of the receptor and, conversely, binding to the receptor-binding site of the ligand.
However, the functional relevance of cholesterol binding to the receptor remains unexplored.
The two crystal components act synergistically; the BinB part is responsible for initial binding to the receptor, and the BinA component confers toxicity (Charles et al. 1997).
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