Sentence examples for binding to the proximal from inspiring English sources

Specifically, using site-directed mutants, we have shown recently that the UIM domain of STAM, abutting its SH3 domain that it uses to bind to AMSH, could facilitate catalysis by binding to the proximal ubiquitin of a diubiquitin substrate.

It inhibits mitochondria ubiquinol cytochrome c oxidoreductase (EC 1.10.2.2, bc1 complex) function by binding to the proximal niche of the quinol oxidation site on the enzyme.

Ets family transcription factors contribute to ERBB2 overexpression by binding to the proximal promoter [ 9].

Proximal histone acetylation allows access for Sp1 binding to the proximal promoter and subsequent transcription (27).

Our data indicate that Pit-1 regulates mammary PRL at transcriptional level by binding to the proximal PRL promoter.

The most efficient gene activation was achieved by clusters of 3-4 sgRNAs binding to the proximal promoters, suggesting a synergistic mode of action.

Lrp binds to the proximal binding sites more tightly than to the distal sites, and the switching from phase-OFF to phase-ON requires a local co-regulator, PapI.

PARP-1 binding to the most proximal element, S/MAR 1, and to three consensus motifs, AGGCC, in its own promoter (basepairs –956 to +100), could be traced by electrophoretic mobility-shift assay.

Here we show that Dax1 depends on Oct4 for its binding to the Nanog proximal promoter.

ChIP assays revealed that methylation treatment significantly reduced SOX9 binding to the COL9A1 proximal promoter, specifically to the putative binding sites BS4 and BS5.

The LWS-LCR is hypothesized to enhance LWS expression in eutherian mammals by looping and binding to the LWS proximal promoter [ 57- 59].