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In both the cases, the spontaneous ligand binding to the proteins occur through entropy driven mechanism, although the interaction of DMACA is relatively stronger in comparison with EDAC.
Molecular docking study indicated the position of PMA-SUC upon binding to the proteins by hydrogen bonding interaction with donor-acceptor within the distance of less than 5 Å in the minimum of binding free energy.
The biarsenical dyes undergo a dramatic enhancement of fluorescence upon binding to the proteins.
In the ITC experiments, the heat released upon putrescine binding to the proteins was measured.
Sucralfate, which does not alter gastric pH, exerts its topical effect on ulcer disease by binding to the proteins of the ulcer site.
We suggested that the functions of L-arginine in solubilization of ADI were probably via the binding to the proteins, thus preventing the formation of inclusion bodies.
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This has important implications in drug development; whether the cation generally binds tightly to the protein active site or binds to the ligand before ligand binding to the protein is an important consideration in designing effective inhibitors of this interaction.
Deletion of this region from the protein abolishes metal binding to the protein [14].
The binding enthalpies of the specific and non-specific DNA binding to the protein differed significantly.
The in silico design of ligands binding to the protein surface instead of deep binding pockets is still a great challenge.
While changes in Cu isotopes can clearly be related to the loss of metal binding to the protein, the change in Zn isotopes is only consistent with a genetic modification of the mice involving the PrP gene.
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