Sentence examples for binding to the protein from inspiring English sources

This has important implications in drug development; whether the cation generally binds tightly to the protein active site or binds to the ligand before ligand binding to the protein is an important consideration in designing effective inhibitors of this interaction.

The binding enthalpies of the specific and non-specific DNA binding to the protein differed significantly.

A change in the channel's outer opening keeps the toxin from binding to the protein and short-circuits its deadliness.

The in silico design of ligands binding to the protein surface instead of deep binding pockets is still a great challenge.

Furthermore, combining the molecular modeling with impedance detection, the accuracy, specificity and predictability of the ligands binding to the protein could be improved.

Meanwhile, molecular docking and molecular dynamic simulations were performed to further elucidate the proposed docking conformations for the inhibitors binding to the protein.

Very recently, glutathione (GSH), either generated by bacteria or derived from host cells, was found to be the essential small molecule cofactor of PrfA through allosteric binding to the protein (Reniere et al., 2015).

While changes in Cu isotopes can clearly be related to the loss of metal binding to the protein, the change in Zn isotopes is only consistent with a genetic modification of the mice involving the PrP gene.

Deletion of the C-terminal 14 amino acids of Azotobacter vinelandii E3 led to its inactivation, decreased its thermostability and also negatively affected FAD-binding to the protein [ 65].

However, since this peptide binds to a surface protein on tumor cells, such a protein could be a cell growth factor or hormone receptor and the binding of this peptide blocks the ligands-binding to the protein and therefore, inhibits their signaling transduction leading to the suppression of tumor cell growth, migration and adhesion capacity.

The binding isotherms indicate release of heat upon Ca2+-binding Ca2+-bindingin and toe thermodynamic proteiners fit results in the vandes of one sethef sithermodynamic unlike Lig A9 and Lig A10; whereas two sets of sites for Lig A4, parametersecause ofithe differesultsin the protein size.