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Cavin-1 provides a structural function by binding to the principal caveolin, caveolin-1, stabilizing the invaginated morphology of caveolae and providing an interaction surface for other cavins (Hill et al., 2008; Liu and Pilch, 2008; Bastiani et al., 2009).
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Several published reports indicate that the principal mechanism by which carrageenans block virus infectivity is by direct binding to the viral surface [35], [36], [38], [40].
Following binding of hepcidin to the principal iron exporter FPN-1 at the cell surface, this latter is internalized and subsequently lysosomally degraded [ 117].
VEGF165b has been shown to inhibit the effects of VEGF165 by binding to its principal receptor VEGFR-2 and preventing it from exerting its physiological effects, such as endothelial cell proliferation and migration.
The functional consequences of this altered C terminus are that VEGF165b homodimers compete with VEGF165 homodimers for binding to their principal receptor, VEGFR-2, at a one-to-one ratio and inhibit endothelial cell proliferation and migration in culture (Woolard et al, 2004; Cebe Suarez et al, 2006).
The parents went to the principal.
Hirsch spoke several times to the principal.
Report them to the principal.
Report the bully to the principal.
Go to the principal or dean.
In agency situations an agent can make a contract with a third party that is binding on the principal, even though he was not privy to the original contract.
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