Sentence examples for binding to the platelet from inspiring English sources

Initial analysis suggests that, like other delta BPVs, the BPV-14 E5 protein could cause mesenchymal proliferation by binding to the platelet derived growth factor beta receptor.

Therefore, the mechanism by which degradation products interfere with fibrinogen binding to the platelet receptor is ligand-ligand interaction rather than binding of the fragments to the receptor.

Binding to human platelets of radioiodinated human fibrinogen and fragments X, Y, D, D1 dimer and E was studied to determine the domain of the fibrinogen molecule responsible for binding to the platelet receptor.

The C4BP binding to the platelet surface was significantly inhibited already with the lowest tested antibody concentration (10 µg/mL; approximately 50% inhibition).

To find out whether there is a connection between the enhanced angiogenic switch and the increased platelet activation in HRG-deficient mice, we depleted RT2/HRG+/+ and RT2/HRG−/− mice of platelets using an antibody binding to the platelet adhesion molecule GP1bα.

Using flow cytometry, immunoprecipitation, a glycan binding array and surface plasmon resonance, we have independently confirmed GPIbα as a receptor for SSL5 on platelets and identified some of the molecular regions of GPIbα that support SSL5 binding to the platelet surface.

Thus, these studies reported the significant enhancement of efficiency of SRH in clot lysis of platelet rich clots, and it may be concluded that SRH targets the platelet rich clot due to the direct selective binding to the activated platelet through GPIIb/IIIa receptor at the platelet rich thrombus and enhances the thrombolytic activity.

FMP-PLNs showed significantly enhanced binding to the activated platelet-covered region, and minimal binding to nontargeted BSA surface, at all shear values.

Although the functional significance of neisserial pilus modification with ChoP remains unknown, it may promote bacterial adhesion through binding to the PAF (platelet-activating factor) receptor [ 74, 75].

While the number of circulating platelets was not significantly affected by treatment with ReoPro (32.4 ± 4.4, Figure 6B), the number of human platelets binding to the developing mouse platelet thrombus was significantly reduced to 1.6 ± 0.5 by the time the Tmax was reached (67 s; Figure 6A and 6C, Supplementary information, Video S3, P < 0.01).

Clopidogrel is a pro-drug that requires metabolism by CYP1A2 and PXR target genes CYP3A, CYP2B6, CYP2C9, and CYP2C19 to form an active metabolite that inhibits ADP-induced platelet activation by irreversibly binding to the P2Y12 ADP platelet receptor.