Sentence examples for binding to the peripheral from inspiring English sources

After binding to the peripheral neurons, the central domain of BoNT helps the LC translocate into cytosol where its proteolytic action on SNARE (soluble NSF attachment protein receptor) proteins blocks exocytosis of acetyl choline leading to muscle paralysis and eventual death.

IP6 binding to the peripheral binding site may also enhance PIP3 affinity in the canonical binding site and sensitize Btk to PIP3 levels.

The most basic analyte studied was acetonitrile and an association constant (Ka) of 0.12 M−1 was calculated its binding to the peripheral silicon centers using the Scatchard method.

In a parallel set of in vitro experiments, we study the irreversible binding to the peripheral benzodiazepine receptors (PBDZR) and dopamine-2 receptors (D2R) with two photoreactive affinity ligands, respectively.

Ligand binding to the peripheral site can block access of substrates or allosterically alter the catalytic efficiency of AChE, but more importantly for our considerations, it interferes with its nonenzymatic adhesion functions that are required for axonogenesis and other developmental events (Bourne et al. 2003; Johnson and Moore 2003; Kousba et al. 2004; Sentjurc et al. 1999).

In ITC experiments, we saw no detectable binding when we added IP6 to a PH-TH module with mutations at both the canonical and the peripheral sites, which confirms that the residual binding of IP6 to the IP4-binding deficient mutant is due to binding at the peripheral binding site.

Instead, two stretches of basic residues mediate peripheral binding to the membrane by electrostatic interaction [ 62].

These steps include a peripheral binding to the NPC, followed by a docking step, and then a translocation step (e.g. by a dilation of the transporter).

The target compounds were designed as dual binding site acetylcholinesterase inhibitors with an arylalkylamine moiety binding at the catalytic site of the enzyme and connected via an alkyl chain to a heterocyclic fragment, capable of binding at the peripheral anionic site of AChE.

On autoradiography however, a focal uptake of 67Ga-P04087 in the valve area was present and histological slices demonstrated localization of peptide binding at the peripheral layer of vegetations.

An association constant (Ka) of 0.12 M−1 was calculated for the binding of ACN to the peripheral silicon centers of 2 using the Scatchard method [ 30– 30].