The binding to the receptor on its own cell plasma membrane initiates a positive feedback loop of growth stimulation as well as it initiates a cascade of events leading to the expression of genes involved in cell cycle progression, cell growth and apoptosis resistance [17], [18], [19].
We have provided evidence that RAP2.1 can directly repress its own expression, creating a self-inhibitory loop by binding to the DREs present in its own promoter.
Example 1 (analyzing regions of low probability) Consider a protein X activating its own expression by cooperatively binding to the promoter that positively regulates its own expression (illustrated in Figure 1).
According to Martin and Smith (1995), amylopectin synthesis begins before amylose synthesis and that amylose is later synthesized within developing starch granules because GBSSI is confined inside the starch granule by its own binding to the granule.
Thus, the EF-G, functioning as a GTPase, PPIase, and a translocase that promotes translocation of the translation complex, facilitates its own binding to the ribosome by indirectly altering the mobility of the L12 CTD.
However, supra-physiological insulin concentrations have generally been used in these studies and it has been questioned whether, on its own, insulin binding to the insulin receptor has any growth-promoting effects [ 119].
SRF autoregulation by binding to its own promoter and binding to the co-activator MKL1 were clearly observed.
This revealed significantly increased binding of PGC1α to its own promoter and unexpected binding to the Drp1 promoter (Fig. 3E).
While binding of Oct4 to its own promoter has a positive regulatory effect, its binding to the Cdx2 promoter is suppressive.
The N-terminus of the antitoxin, which comprises diverse DNA-binding structural motifs, is mainly involved in mediating transcriptional regulation of the operon by binding to its own upstream DNA.
