Sentence examples for binding to the outer from inspiring English sources

Here, we explore the modulation of a very long-lived inactivated state, ultraslow inactivation (IUS), by ligand binding to the outer vestibule in voltage-gated Na+ channels.

The high cell selectivity could stem from their preferential binding to the outer cell membranes containing negative charges and high fluidity.

Bax is a cytosolic protein that responds to various apoptotic signals by binding to the outer mitochondrial membrane, resulting in membrane permeabilization, release of cytochrome c, and caspase-mediated cell death.

The antidiuretic action of vasopressin is thought to depend upon its binding to the outer surface of the kidney tubule, resulting in an increase in the uptake of sodium from the urine into the tubule cells and, concurrently, an increase in the uptake of water.

In the sectional view of seam loop c in Fig. 9 a not binding to the outer sheet metal can be seen as a blue hole in the X-ray computer tomography.

Other antidiabetes drugs work in various ways, such as increasing insulin production by the pancreas or binding to the outer portion of the insulin receptor, but they may have serious side effects, such as excessively low blood sugar or blood pH, gastrointestinal problems, or liver failure.

Rhodamine-labeled Arachis hypogaea lectin specifically binding to the sperm outer acrosomal membrane and fluorescein-labeled Pisum sativum lectin with affinity to the acrosomal content were used in combination with the membrane semipermeant DNA dye Hoechst 33342 (Invitrogen, Paisley, UK).

HKII binding to the mitochondrial outer membrane reduces cellular ROS production and protects against cell death in cardiomyocytes (Sun et al, 2008; Miyamoto et al, 2008; Wu et al, 2011).

Pitkänen et al. [ 77] suggested that this could be the consequence of drug binding to melanin: the outer BRB contains melanin, which is a molecular site for basic and lipophilic drug binding and interaction [ 78], influencing permeation.

This implies some restriction of diffusion and possibly binding to the high surface area of the outer biofilm.

Colistin acts on the bacterial cell membrane by binding to the LPS (lipopolysaccharide) component of the outer membrane of sensitive Gram-negative bacteria, increases cell permeability and leads to cell lysis and bacterial cell death.