Most actions of cortisol are thought to be mediated by the glucocorticoid receptor (GR), which upon binding to the hormone, moves into the nucleus and acts as a transcription factor that interacts with specific promoter regions known as glucocorticoid responsive elements (GREs) [ 4].
2) Alternatively, the gene may be silent, in which case Hairy binding to the gene in interstripe nuclei would not alter its silence.
β-Catenin is the pivotal component in the Wnt pathway, and its accumulation in the cytoplasm will promote translocation into the nucleus, then binding to the TCF/LEF for transcriptional activation of downstream genes [42].
Reduction of intracellular PKAcα levels by RNA interference inhibited HSF1-S320 preventedlaccumulationnted accumulatiof of HSF1 in the nucleus and binding to the hsp70.1 promoter and decreased heat shock transcription.
The MDM2 protein inhibits p53 transactivation activity and promotes its export from the nucleus by binding to the transcriptional activation domain of p53 [ 1] and acts as an ubiquitin ligase upon p53 pushing fast degradation of the suppressor [ 2, 3].
In Scenario 6 we explored the issue of competing delayed reactions stemming from two molecular species, A c and D c, entering the nucleus and binding to the same partner species B n.
Activation of nuclear factor kappa-B (NF-κB) results in its translocation from the cytoplasm to the nucleus and binding to the promoters of a large number of genes, including those encoding proinflammatory cytokines and other mediators that can contribute to organ system dysfunction in severe infection.
The nuclei in the latter case showed violet purplish color, which suggests that some of the OGFrs had been translocated into the nuclei upon binding to the Met-Enk.
The resulting images are representations (sections or projections) of the 3D dye binding to the chromatin structure of fixed nuclei.
This finding suggests that the major function of Kap104p lies in returning mRNA binding proteins to the nucleus after mRNA export.
