Sentence examples for binding to the nucleotide from inspiring English sources

These results might be influenced by the affinity of binding to the nucleotide rather than the ability of the helicase to hydrolyse a particular nucleotide and simultaneously unwind the duplex, for example.

As seen in other GTPase GEF complexes, the effect of the conformational changes induced in switch I and II is to disrupt binding to the nucleotide and Mg2+ ion, and thereby promote nucleotide release.

This is because expansion of the molecular area of 1 by binding to the nucleotides is thermodynamically unfavourable at higher pressures.

VER, which binds to the nucleotide binding site of HSP70, acts as an ATP-competitive inhibitor.

It was recently reported that VER155008 could bind to the nucleotide binding site of Hsp70 protein, and then could act as ATP-competitive inhibitor, which prevents allosteric control between nucleotide binding domain and substrate binding domain, although 2-phenylethynesulfonamide interacted with the substrate binding domain of Hsp70 in an unspecific and detergent-like fashion [ 32].

Prior results showed that either ADP or ATP could bind to the nucleotide binding site of PII and that wild-type heterotrimers could sense the ratio of ATP to ADP, a reflection of the adenylate energy charge (10).

The structures of human PDK1 and PDK3 with AZD7545, dichloroacetate, and radicicol (antitumor compound) revealed that AZD7545 binds to the lipoyl-binding pocket in the N-terminal region of PDK1 and prevents PDK1 from binding to the E2·E3BP core, while radicicol binds to the nucleotide-binding site of PDK3 and inhibits its activity by competing with ATP for the nucleotide-binding site.

CKI-7 binds to the nucleotide-binding pocket of the enzymes and its binding alters the conformation of the nucleotide-binding loop, the segment homologous to the glycine-rich loop in eurkaryotic protein kinases.

The first domain, EF-TU, is the catalytic domain, which is responsible for the binding to the guanine nucleotide [ 82].

CyP-D is regulated by acetylation, which potentiates its binding to the adenine nucleotide translocase and lowers the Ca2+ threshold for PT pore formation [ 8].

While most of the functional studies of WRKY proteins indicate a binding to the conserved nucleotide consensus sequence TGAC(C/T) of the W-box, the binding to another cis-element called SURE has also been described [ 15].