Sentence examples for binding to the negative from inspiring English sources

Note that the non-specific binding to the negative control sequence (CRE, cAMP response element) is within this latter range of affinities (Kd = 6.6 µM).

APE1 was also identified as a direct trans-acting factor for repressing genes by binding to the negative calcium-response element in their promoters.

Recombinant HOT1 bound specifically to telomeric repeats, whereas no binding to the negative control repeat fragments (5′-GTGAGT-3′) was detected.

By contrast, we did not detect Trx binding to the negative control region located 7.5 kilobases 3ʹ from the btd transcription unit (Petruk et al., 2012).

We previously showed that B7.2 molecules expressed by SGEC display distinctive binding properties denoted by the functional interaction with CD28 receptor and reduced binding to the negative immune regulator CTLA4.

In order to compare the levels of antibodies eluted from different lung specimens, the OD values generated for IgG binding to candidate lung antigens were standardized by expressing them as ratios to the OD values of the same eluates for binding to the negative control antigen, thyroglobulin.

Antibodies that compete with Notch1 ligand binding or that bind to the negative regulatory region can act as potent inhibitors of Notch1 signaling.

We therefore speculate that the positively charged surface of kurtoxin is an important determinant of its binding to the conserved negative domain in Cav3 (T-type) Ca2+ channels.

Of note, the Co-IP experiments show strongly increased physical association of Coro1A with the constitutively active mutant PKCθ A149E, while the binding to the dominant-negative PKCθ K409R mutant remained unaltered when compared to wild-type PKCθ.

Therefore, we designed the anisotropy binding titration assays using the NRE present in the TSHβ promoter (TSH NRE) [15] to detect the TRβ1 binding to this negative response element in terms of dissociation constants (Kds).

All of these PAMs potentiate mGlu5-mediated responses by binding to the well-characterized, negative allosteric modulator MPEP binding site.