Sentence examples for binding to the native from inspiring English sources
Recently, Sun et al. (2016) designed an immunogen containing four tandem 10E8 epitope repeats that exhibits α-helical conformation and the key amino acids W and F, which can point toward different directions when the long peptide binds the plasma membrane, thereby strengthening the induction of antibodies capable of binding to the native conformation of MPER on the viral envelope.
We demonstrated that the BD-N and BD-C2 binding domains are sufficient for CaM binding to the native channel, and, therefore, that BD-C1 is unable to bind CaM independently.
The protein's folding/unfolding equilibrium is shifted by a free energy equal to that calculated from the metal ion's preferential binding to the native protein.
(A,B) Enforced expression of NPM-ALK into RR cells derived from GOTO or SK-N-SH showed crizotinib NPM-ALK binding while no binding to the native ALK.
The scFv mimicked the antibody in binding to the native serum-derived HCV particles from patients, as well as to envelope E1E2 complexes and E1, E2 glycoproteins carrying the viral epitope.
Metal-mediated stability is the consequence of differential binding to the native and unfolded states.
Thermodynamic analysis revealed that all variants bound metal to the unfolded state, and the observed metal-mediated stability is a consequence of differential binding to the folded native state and unfolded structures, although the dominant factor for binding to the unfolded state is unclear.
This data suggest that these fragments occupy the classical orthosteric binding pocket of the β2 adrenoceptor and that they are bonafide receptor ligands capable of binding to the receptor in native membranes.
None of these aza inhibitors displayed tighter binding to the enzyme than the native substrate chorismate or greater inhibitory action than the previously reported ether analogue, 3. Furthermore, no time-dependent loss of enzyme activity was observed in the presence of the two potentially reactive aza inhibitors (7 and 9).
First, receptor binding to the canyon of the native virion induces structural rearrangements in the GH loop of VP1.
Our study demonstrated that M2 VLP vaccination induces antibodies binding to the M2 extracellular peptide, the native form of M2 expressed on cell surfaces, as well as to purified virions regardless of HA subtype.
