Sentence examples for binding to the mutant from inspiring English sources
Pharmacological treatments may target the ΔF508 CFTR structural defect directly by binding to the mutant protein and/or indirectly by altering cellular protein homeostasis (proteostasis) to promote ΔF508 CFTR plasma membrane targeting and stability.
When neddylation was inhibited, CAND1 binding to the mutant Cul1 was no longer reduced compared to wild type.
Competition ELISA assays were performed to better quantify the differences of antibody binding to the mutant peptides observed in the above Western blotting experiments.
Thus small molecules that decrease the rate of either MBNL1 or hnRNP H binding to the mutant DMPK RNA may serve to increase its transport out of the nucleus.
The mutated gene encodes a E155G substitution in EF4 of the GCAP1 protein; Ca2+ binding to the mutant GCAP1 is reduced to only two hands (EF2 and EF3) and thereby reduces the feedback loop [17], [40] whereby cyclase activity is reduced as Ca2+ concentrations in photoreceptors are brought back to dark-state levels.
In contrast, sera from persons infected with other flaviviruses showed significantly decreased binding to the mutant protein.
ITC was used to determine the affinity of tetracycline binding to the mutants.
To test whether the inhibitory role of the Ubl was linked to its ability to bind RING1, we tested pUb binding to the L266K mutant.
These results suggest that the D205A,D207A and the Del202 208 mutant proteins each had reduced binding to purified integrin αvβ3, and that the reduction in integrin binding to the D205A,D207A mutant protein was less severe than to the Del202 208 mutant protein.
Crizotinib binding to the MET mutant Y1230C is weakened 15-fold in a cellular assay [94], supporting the view that the pi stacking interaction in important in vivo.
In addition, most of these new CD4bs-specific mAbs also showed decreased binding to the CD4i mutant, suggesting that they may span a broader, as yet undescribed region that includes elements of the CD4bs and CD4i sites.
