Sentence examples for binding to the mouse from inspiring English sources

Although these two mutations do not affect the binding to the mouse leptin receptor, they cause reduced biological activity [28].

Radioligand binding to the mouse A3 receptor was inhibited by only 10% at 10 μ M (Table 1).

A hybridoma (mAb C) that did not interfere with in vitro fertilization in mice and was capable of binding to the mouse sperm cell surface was identified.

Although conserved CSL sites were found in the mouse and human NANOG regulatory regions, we were unable to detect intracellular NOTCH1 binding to the mouse Nanog regulatory region, suggesting that NOTCH1 may indirectly regulate Nanog expression (data not shown).

We have not, however, been able to demonstrate HNF4α binding to the mouse cingulin promoter in the small intestinal mucosa, which indicates that either HNF4α is not regulating cingulin in the mouse or that an HNF4α binding site in the mouse cingulin promoter is located outside the investigated region.

PCB 104 was found to 1) compete with tritiated 17beta-estradiol (E2) for binding to the mouse uterine estrogen receptor (ER); 2) induce gene expression in MCF-7 human breast cancer cells transiently transfected with the Gal4-human ER chimeric construct (Gal4-HEGO) and the Gal4-regulated lucifereporterorter gene (17m5-G-Luc); and 3) increase MCF-7 cell proliferation in a dose-dependent manner.

ChIP assays of mouse primary keratinocytes under growing conditions demonstrated p63 binding to the corresponding mouse sequences, the strongest binding region being the +1.8 kb region from the Fgfr2 transcriptional start site (TSS) (Fig 4D; Supporting Information Fig S7B).

Failure of POM5 binding to the mutated mouse PrP was also confirmed by SPR (data not shown).

While the number of circulating platelets was not significantly affected by treatment with ReoPro (32.4 ± 4.4, Figure 6B), the number of human platelets binding to the developing mouse platelet thrombus was significantly reduced to 1.6 ± 0.5 by the time the Tmax was reached (67 s; Figure 6A and 6C, Supplementary information, Video S3, P < 0.01).

As with human CD32B, the optimized Fc domain imparts reduced binding to CD32, the mouse inhibitory FcγR (mice lack a CD32A ortholog), and reduced binding to murine CD64 and this contrasts with the minimal change observed with human CD64.

We identify the DREAM complex binding to the CHR of mouse and human \ cyclin B2\) promoters in \(G_0\).