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One MAb recognizing the highly conserved N-terminal portion of consensus M2e displayed high binding to the majority of M2e variants from natural viral isolates, including highly pathogenic avian strains, which were recently reported to infect humans.
This specificity of AO for highly crystalline HAp additionally may reduce nonspecific binding to the majority of the noncancerous bone.
No binding to the majority of these proteins indicates that the released actin is incorrectly folded (see e.g. mutant 360(A5)* in Fig. 1B).
Indeed, substitution of a key glutamate residue (E253) in the ligand binding pocket of the C-terminal binding domain of the multidrug transcription regulator, BmrR, resulted in the abolition of binding to the majority of representative cationic co-activators (11).
While our ChIP-chip data only show Hmt1-binding to approximately 40% of all tDNAs, the observation of Hmt1's physical association with Bdp1 suggests that Hmt1 is binding to the majority of the tDNAs, if not all of them.
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Interestingly, this gene displays maternal allele-specific binding of ZFP57, a DNA-binding protein that specifically binds to the majority of imprinted genes and protects them from demethylation after fertilization (Quenneville et al., 2011).
However, since this case is expected to be the exception rather than the rule, it is unlikely to be the cause of a lack of HSF binding to the promoters of the majority of the genes identified.
On the other hand, only a few polymer segments are binding to the adsorbent surface; the overwhelming majority of them are in the solution building loop and tail structures of adsorbed macromolecules.
Of the ten plasminogen-binding proteins identified with the ligand affinity method, only one (phosphoglycerate kinase) was predicted to contain a carboxyl-terminal lysine, suggesting that plasminogen binding to a majority of the surface receptors could be mediated in part by internal lysine residues, as demonstrated by the inhibition of plasminogen binding by the lysine analog εACA (Fig. 3C).
As a control, this minimal sumoylation of HDAC1 did not perturb its binding to CoREST, because the majority of HDAC1 remained unsumoylated and retained the ability to bind to CoREST (Figure 6C).
Overall, some interesting SAR patterns emerged, with hydrophobic features favoured at the N4-position of the 1,2,4-triazole ring system and an acetamide side chain making contributions to binding in the majority of compounds.
More suggestions(15)
binding to the p15
binding to the cue
binding to the yeast
binding to the waaA
binding to the lipid
binding to the γδ
binding to the brain
binding to the a7-nAChR
binding to the promoter
binding to the soil
binding to the spa
binding to the receptor
binding to the sugar
binding to the gold
binding to the reference
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